Endothelial cells are remarkably heterogeneous in both morphology and function, and they play critical roles in the formation of multiple organ systems.In addition endothelial cell dysfunction can contribute to disease processes, including diabetic nephropathy, which is a leading cause of end stage renal disease.In this report we define the compreh
Challenging Pronatalism Is Key to Advancing Reproductive Rights and a Sustainable Population
Social and environmental justice organisations have silenced discourse on human overpopulation due to fear of any association with reproductive coercion, but in doing so they have failed to acknowledge the oppressive role of pronatalism in undermining reproductive autonomy.Pronatalism, which comprises cultural and institutional forces that compel r
Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications
Abstract The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that exert a profound influence on tumor initiation and progression.Within the TME, angiogenesis is predominantly orchestrated by endothelial cells (ECs), which foster the proliferation and metastas